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Production of mannosylglycerate in Saccharomyces cerevisiae by metabolic engineering and bioprocess optimization.

Cristiana FariaNuno BorgesIsabel RochaHelena Santos
Published in: Microbial cell factories (2018)
In the present study, the yield and productivity of MG were increased by overexpression of the GDP-mannose pathway and optimization of the mode of cultivation. A maximum of 15.86 mgMG g DCW -1 was achieved in batch cultivation and maximal productivity of 1.79 mgMG g DCW -1  h-1 in continuous mode. Additionally, a positive correlation between MG productivity and growth rate/dilution rate was established, although this correlation is not observed for MG yield.
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