Intrahepatic cholangiocarcinoma induced M2-polarized tumor-associated macrophages facilitate tumor growth and invasiveness.

Hui YuanZelong LinYingjun LiuYuchuan JiangKe LiuMengxian TuNan YaoChen QuJian Hong

Published in: Cancer cell international (2020)

Our results indicated that M2-polarized macrophages induced by ICC promote tumor growth and invasiveness through IL-10/STAT3-induced EMT and might be a potential therapeutic target for ICC.

Keyphrases

high glucose
diabetic rats
epithelial mesenchymal transition
drug induced
cell proliferation
endothelial cells
risk assessment
signaling pathway