Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis.

Tingting PanShaoqiong SunYang ChenRui TianErzhen ChenRuoming TanXiaoli WangZhaojun LiuJialin LiuHongping Qu

Published in: Critical care (London, England) (2022)

The inhibition of glycolysis contributed to neutrophil immunosuppression during sepsis and might be controlled by PI3K/Akt-HIF-1α pathway-mediated LDHA downregulation. Our study provides a scientific theoretical basis for the management and treatment of patients with sepsis and promotes to identify therapeutic target for the improvement of immune function in sepsis.

Keyphrases

pi k akt
signaling pathway
septic shock
cell proliferation
acute kidney injury
intensive care unit
cell cycle arrest
transcription factor
cell death
replacement therapy
smoking cessation