TLR7/8 Activation in Immune Cells and Muscle by RNA-Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis.
Yin WuAditee DeshpandeNicholas GeraciPetra BuddeVera SellersPhanindra VelisettyChia-Chi SunFatima StrandCarmina BhavsarTimothy B NiewoldMark A JensenIrina KalatskayaKavita Y SarinDavid FiorentinoAndrew T BenderPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Our results suggest that patients with IIM have autoantibodies in their blood causing TLR7/8 activation, which leads to inflammation in muscles with potential deleterious effects.