Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
Richard P WhitlockEmilie P Belley-CoteDomenico PaparellaJeff S HealeyKatheryn BradyMukul SharmaWilko ReentsPetr BuderaAndony J BaddourPetr FilaPhilip J DevereauxAlexander Bogachev-ProkophievAndreas BoeningKevin H T TeohGeorgios I TagarakisMark S SlaughterAlistair G RoyseShay McGuinnessMarco AlingsPrakash P PunjabiC David MazerRichard J FolkeringaAndrea ColliÁlvaro AvezumJuliet NakamyaKumar BalasubramanianJessica VincentPierre VoisineAndre LamySalim YusufStuart J Connollynull nullPublished in: The New England journal of medicine (2021)
Among participants with atrial fibrillation who had undergone cardiac surgery, most of whom continued to receive ongoing antithrombotic therapy, the risk of ischemic stroke or systemic embolism was lower with concomitant left atrial appendage occlusion performed during the surgery than without it. (Funded by the Canadian Institutes of Health Research and others; LAAOS III ClinicalTrials.gov number, NCT01561651.).
Keyphrases
- left atrial appendage
- atrial fibrillation
- cardiac surgery
- acute kidney injury
- catheter ablation
- left atrial
- oral anticoagulants
- direct oral anticoagulants
- minimally invasive
- coronary artery bypass
- heart failure
- percutaneous coronary intervention
- surgical site infection
- acute coronary syndrome
- mesenchymal stem cells
- left ventricular
- cell therapy
- blood brain barrier