Significant reduction in hemarthrosis in boys with severe hemophilia A: The China hemophilia individualized low-dose secondary prophylaxis study.

Runhui WuXiaojing LiWanru YaoQing ZhangMin ZhouNingning ZhangSheng YangZhenping ChenYan WangYangying KuangLing TangYingzi ZhenAudrey AbadAndrea S DoriaPamela Hilliard Danial M IgnasPrasad MathewDerek StephensVictor S BlanchetteKoon-Hung Luke

Published in: Research and practice in thrombosis and haemostasis (2021)

A low-dose, individualized prophylaxis protocol, guided by individual bleeding profiles and serial assessment of joint status, enables escalation of treatment intensity in boys with severe hemophilia A, leading to a significant reduction in bleeding events and reduction in target joint bleeding.

Keyphrases

low dose
atrial fibrillation
high dose
early onset
clinical trial
drug induced
combination therapy
replacement therapy