A new dineolignan with anti-β-amyloid aggregation activity from the fruits of crataegus pinnatifida bge.

A new dineolignan, crataeguslignan A (1), along with one known dineolignan (2) were isolated from the fruits of Crataegus pinnatifida Bge. Its chemical structure was identified by comprehensive spectroscopic analyses. All the isolated compounds were investigated with regard to their Aβ1-42 inhibition activity. Among them, 1 displayed the most potent Aβ1-42 inhibitory ability with the inhibition rate of 85.2% at the concentration of 20 μM.