Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia.
Thomas D CardaciBrandon N VanderVeenBrooke M BullardSierra J McDonaldChristian A UngerReilly T EnosDaping FanKandy T VelázquezNorma FrizzellEspen E SpangenburgE Angela MurphyPublished in: Journal of cachexia, sarcopenia and muscle (2023)
Taken together, these results demonstrate that obesity is not protective against cachexia and suggest exacerbated impairments to mitochondrial function and quality control with a particular disruption in the removal of damaged mitochondria. Our findings highlight the need for consideration of the severity of obesity and pre-existing metabolic conditions when determining the impact of weight status on cancer-induced cachexia and functional mitochondrial deficits.
Keyphrases
- quality control
- insulin resistance
- weight loss
- metabolic syndrome
- weight gain
- skeletal muscle
- papillary thyroid
- high fat diet induced
- type diabetes
- oxidative stress
- squamous cell
- body mass index
- traumatic brain injury
- physical activity
- cell death
- high glucose
- lymph node metastasis
- childhood cancer
- young adults
- drug induced
- endoplasmic reticulum