Double-Oxidative Dehydrogenative [4+2]-Cyclization/Dehydrogenation/Oxygenation Tandem Reaction of N-Arylglycine Derivatives with Cumenes.

Double-oxidative dehydrogenative (DOD) cyclization is one of the most straightforward strategies for the synthesis of cyclic compounds. A novel approach to substituted 3,4-dihydroquinoline-3-one derivatives via a Cu(II)/DDQ/O2 system-catalyzed DOD [4+2]-cyclization/dehydrogenation/oxygenation cascade reaction of N-arylglycine derivatives, cumenes, and O2 has been developed.