Association between incidental statin use and skeletal myopathies in patients treated with immune checkpoint inhibitors.
Zsofia Dora DrobniSean P MurphyRaza M AlviCharlotte LeeJingyi GongRamya C MosarlaPaula K RambaratSarah B HartmannHannah K GilmanLeyre ZubiriVineet K RaghuRyan J SullivanAmna ZafarDaniel A ZlotoffMeghan E SiseAmanda C GuidonKerry L ReynoldsMichael DouganTomas G NeilanPublished in: Immunotherapy advances (2021)
In this large cohort of ICI-treated patients, a higher risk was observed for skeletal myopathies and elevation in CK levels in patients undergoing concurrent statin therapy. Prospective observational studies are warranted to further elucidate the potential association between statin use and ICI-associated myopathies.
Keyphrases
- cardiovascular disease
- patients undergoing
- end stage renal disease
- coronary artery disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- low density lipoprotein
- squamous cell carcinoma
- mesenchymal stem cells
- patient reported outcomes
- climate change
- bone marrow
- replacement therapy