Alcohol Reduces Arterial Remodeling by Inhibiting Sonic Hedgehog-Stimulated Stem Cell Antigen-1 Positive Progenitor Stem Cell Expansion.

Emma FitzpatrickXu HanWeimin LiuEoin CorcoranDenise BurtenshawDavid MorrowJay-Christian HeltPaul A CahillEileen M Redmond

Published in: Alcoholism, clinical and experimental research (2017)

EtOH reduces SHh-responsive Sca1+ progenitor cell myogenic differentiation/expansion in vitro and during arterial remodeling in response to ligation injury in vivo. Regulation of vascular Sca1+ progenitor cells in this way may be an important novel mechanism contributing to alcohol's cardiovascular protective effects.

Keyphrases

stem cells
alcohol consumption
skeletal muscle
signaling pathway
mesenchymal stem cells
bone marrow