Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension.

Lingli WangJan Renier MoonenAiqin CaoSarasa IsobeCaiyun G LiNancy F TojaisShalina TaylorDavid P MarcianoPin-I ChenMingxia GuDan LiRebecca L Harper Nesrine El-BizriYuMee KimKryn StankunasMarlene Rabinovitch

Published in: Circulation research (2023)

Agents that neutralize the elevated ARRB2 resulting from loss of BMPR2 in PASMC could prevent or reverse the aberrant hypocontractile and hyperproliferative phenotype of these cells in PAH.

Keyphrases

smooth muscle
pulmonary arterial hypertension
pulmonary hypertension
induced apoptosis
pulmonary artery
cell cycle arrest
single cell
cell therapy
endoplasmic reticulum stress
signaling pathway
oxidative stress
stem cells
mesenchymal stem cells
cell proliferation
coronary artery
pi k akt
bone marrow