Total Synthesis of Caesalpinnone A.
Zhigang LiuYifei MengPengrui YuanZhengshen WangJin-Ming GaoHuaiji ZhengPublished in: Organic letters (2019)
Total synthesis of caesalpinnone A was achieved in 12 steps starting from resorcinol. Key features of the synthesis include BINOL-phosphoric acid catalyzed [4 + 2] cycloaddition, trans-selective nucleophilic substitution, deallylation/oxa-Michael addition cascade, and late-stage photo-Fries rearrangement.