Intradiscal injection of monosodium iodoacetate induces intervertebral disc degeneration in an experimental rabbit model.

The results of this study showed, for the first time, that the intradiscal injection of MIA induced degenerative changes of rabbit IVDs in a time- and dose-dependent manner. This study suggests that MIA injection into rabbit IVDs could be used as an animal model of IVD degeneration for developing future treatments.