Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load.
Anita SchuchElahe Salimi AlizeiKathrin HeimDominik WielandMichael Muthamia KiraitheJanine KemmingSian Llewellyn-LaceyÖzlem SogukpinarYi NiStephan UrbanPeter ZimmermannMichael NassalFlorian EmmerichDavid A PriceBertram BengschHendrik LuxenburgerChristoph Neumann-HaefelinMaike HofmannRobert ThimmePublished in: Gut (2019)
Overall, the molecular mechanisms underlying impaired T cell responses differ with respect to the targeted HBV antigens. These results have potential implications for immunotherapeutic approaches in HBV cure.