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Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load.

Anita SchuchElahe Salimi AlizeiKathrin HeimDominik WielandMichael Muthamia KiraitheJanine KemmingSian Llewellyn-LaceyÖzlem SogukpinarYi NiStephan UrbanPeter ZimmermannMichael NassalFlorian EmmerichDavid A PriceBertram BengschHendrik LuxenburgerChristoph Neumann-HaefelinMaike HofmannRobert Thimme
Published in: Gut (2019)
Overall, the molecular mechanisms underlying impaired T cell responses differ with respect to the targeted HBV antigens. These results have potential implications for immunotherapeutic approaches in HBV cure.
Keyphrases
  • hepatitis b virus
  • liver failure
  • dendritic cells
  • immune response
  • risk assessment
  • cancer therapy
  • climate change