Biologically Safe, Versatile, and Smart Bismuthene Functionalized with a Drug Delivery System Based on Red Phosphorus Quantum Dots for Cancer Theranostics.
Huaibing SongJun WangBin XiongJiayuan HuPei ZengXiaoming LiuHuageng LiangPublished in: Angewandte Chemie (International ed. in English) (2022)
Two-dimensional nanomaterials are attracting attention for cancer therapy. However, high toxicity, insensitivity to external stimuli and single therapeutic modality are still key issues hindering their clinical application. Therefore, the construction of a safe, intelligent and versatile nanocomposite is needed to meet clinical expectations. Herein, we developed a nanocomposite of Bi@RP-PEG-DOX with 2D bismuthene loaded with 0D red phosphorus quantum dots and DOX. The nanocomposite with DOX loading capacity (ca. 250 %) and photothermal conversion efficiency (ca. 54 %) showed both photothermal and photodynamic effects and a sensitive response of drug release to the acidic tumor microenvironment or NIR II laser irradiation. The nanocomposite exhibits good biosafety. Through the X-ray attenuation properties of bismuth, the nanocomposite serves as an excellent CT contrast agent, providing potential to perform CT-guided therapy.
Keyphrases
- quantum dots
- cancer therapy
- drug release
- drug delivery
- reduced graphene oxide
- sensitive detection
- dual energy
- contrast enhanced
- photodynamic therapy
- computed tomography
- energy transfer
- image quality
- magnetic resonance
- solid phase extraction
- oxidative stress
- papillary thyroid
- carbon nanotubes
- squamous cell carcinoma
- young adults
- risk assessment
- heavy metals
- highly efficient
- stem cells
- gold nanoparticles
- squamous cell
- bone marrow
- lymph node metastasis
- protein kinase
- sewage sludge
- replacement therapy
- high resolution
- simultaneous determination
- high speed
- tandem mass spectrometry