Prognostic Significance of Bone Metastasis in Soft Tissue Sarcoma Patients Receiving Palliative Systemic Therapy: An Explorative, Retrospective Pooled Analysis of the EORTC-Soft Tissue and Bone Sarcoma Group (STBSG) Database.

Georgios Kantidakis Saskia Litière André B P van Kuilenburg Marta Fiocco Ian R Judson Winette T A van der GraafAntoine ItalianoSandrine Marréaud Stefan SleijferGunhild MechtersheimerChristina Messiou Bernd Kasper

Published in: Sarcoma (2022)

Adult STS patients receiving palliative systemic therapy with bone metastasis carried an overall worse prognosis than STS patients without bone metastases. Skeletal metastasis was detrimental for both OS and PFS, independent of the treatment line. Findings may have implications for the management of these patients.

Keyphrases

soft tissue
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
bone mineral density
peritoneal dialysis
prognostic factors
emergency department
stem cells
patient reported outcomes
body composition
bone loss
replacement therapy