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[Investigation of ligand-receptor interaction and biodistribution of a drug containing cattle retinal polypeptides in various administration routes].

Nicolay VerlovArtem DorotenkoL S GulinaA V KalatanovaA P TrashkovV S Burdakov
Published in: Vestnik oftalmologii (2021)
According to the study results, the peptide drug binds to receptors associated with the loss of retinal ganglion cells. Interaction with these receptors potentially provides the test subject with neuroprotective effect. The content dynamics of the studied drug in the blood of animals depends on the route of administration and the amount of drug administered. At the time point of 0.5 hours for intravenous and intramuscular administration in the dose of 1.7 mg/kg, the studied drug has sufficiently high bioavailability in the tissues of the brain and eye. The data suggest that the main route of excretion of the studied drug is through kidneys.
Keyphrases
  • adverse drug
  • gene expression
  • emergency department
  • induced apoptosis
  • high dose
  • optical coherence tomography
  • cell death
  • cell proliferation
  • signaling pathway
  • white matter
  • deep learning
  • endoplasmic reticulum stress