A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors.

Hinke SiebingaB J de Wit-van der VeenJ H BeijnenM P M StokkelT P C DorloA D R HuitemaJ J M A Hendrikx

Published in: EJNMMI research (2021)

To conclude, biodistribution of 68Ga-DOTATATE was described with a whole-body PBPK model, where tissue distribution was mainly determined by variability in SSTR2 organ expression and differences in administered peptide amounts.

Keyphrases

pet ct
neuroendocrine tumors
end stage renal disease
ejection fraction
newly diagnosed
positron emission tomography
computed tomography
pet imaging
patient reported outcomes