Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice.
Wei-Jia ChenJing-Qi NiuYi-Ting ChenWen-Jing DengYing-Ying XuJing LiuWei-Feng LuoTong LiuPublished in: The journal of headache and pain (2021)
These results indicate that unilateral injection of BoNT/A attenuated bilateral mechanical pain hypersensitivity and anxiety-like behaviors in dIoN-CCI mice, and the analgesic effects of BoNT/A may be associated with the inhibition of TLR2-mediated neuroinflammation in the TNC.
Keyphrases
- neuropathic pain
- spinal cord
- spinal cord injury
- inflammatory response
- toll like receptor
- lipopolysaccharide induced
- high fat diet induced
- lps induced
- immune response
- traumatic brain injury
- ultrasound guided
- sleep quality
- cognitive impairment
- cerebral ischemia
- case report
- chronic pain
- type diabetes
- brain injury
- metabolic syndrome
- skeletal muscle
- subarachnoid hemorrhage
- blood brain barrier
- depressive symptoms