Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters.

Anna Jinxia ZhangAndrew Chak-Yiu LeeJasper Fuk-Woo ChanFeifei LiuCan LiYanxia ChenHin ChuSiu-Ying LauPui WangChris Chung-Sing ChanVincent Kwok-Man PoonShuofeng YuanKelvin Kai-Wang ToHong-Lin ChenKwok-Yung Yuen

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Simultaneous or sequential coinfection by SARS-CoV-2 and A(H1N1)pdm09 caused more severe disease than monoinfection by either virus in hamsters. Prior A(H1N1)pdm09 infection lowered SARS-CoV-2 pulmonary viral loads but enhanced lung damage. Whole-population influenza vaccination for prevention of coinfection, and multiplex molecular diagnostics for both viruses to achieve early initiation of antiviral treatment for improvement of clinical outcome should be considered.

Keyphrases

sars cov
respiratory syndrome coronavirus
pulmonary hypertension
oxidative stress
early onset
disease virus
single molecule
acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
single cell
real time pcr