Three new diterpenoids from the leaves of Salvia lachnostachys .

Three new diterpenoids, demethylfruticuline B ( 1 ), 20-hydroxyfruticuline B ( 2 ), and 6-hydroxyisofruticuline A ( 3 ) were isolated from the leaves of Salvia lachnostachys Benth, together with five known compounds: fruticuline B ( 4 ), fruticuline A ( 5 ), demethylfruticuline A ( 6 ), heterobetulinic acid ( 7 ), and maslinic acid ( 8 ). The known compounds 7 - 8 are being reported for the first time in this species. Compounds 1 and 4 - 6 were tested for antioxidant activity using the ORAC-FL method, and the antioxidant capacity was measured as relative trolox equivalent. All compounds were active, with values of relative trolox equivalent varying between 1.20-2.42. The most active compound was demethylfruticuline B ( 1 ).