Scary black nodes.
Jyotsna Naresh BhartiArsha B SoudaminiDarwin KaushalPublished in: Diagnostic cytopathology (2021)
Anthracosis is associated with smoking, air pollution, tuberculosis infection, and exposure to biomass. Anthracosis commonly involves bronchial trees and rarely lymph nodes. We report an unusual case of a 44-year-old female presented with painless supraclavicular swelling for 1 month. A fine-needle aspiration cytology examination was done from the swelling. The smears were markedly cellular and showed the presence of sheets, clusters, and singly scattered round to oval cells with mild anisonucleosis, fine to coarse chromatin, few with tiny nucleoli, and cytoplasm containing abundant black coarse pigment. At many places, the fibroblasts and lymphocytes were admixed with histiocytes containing pigment. The cell block made showed cell morphology similar to that described above for fine-needle aspiration smears. The immunohistochemistry on the cell block and special stains helped to ascertain the nature of pigment and cell type. The final diagnosis of the anthracofibrosis lymph node was made. Due to its rarity, its awareness is a must; otherwise, it can be mistaken for metastatic deposits from malignant melanoma and can result in unnecessary surgical intervention and morbidity. However, it shall be considered one of the differential diagnoses of neck nodes in nonsmoker females with a history of domestic wood smoke exposure.
Keyphrases
- fine needle aspiration
- lymph node
- ultrasound guided
- air pollution
- single cell
- sentinel lymph node
- cell therapy
- molecular dynamics simulations
- molecular dynamics
- squamous cell carcinoma
- induced apoptosis
- gene expression
- emergency department
- stem cells
- mycobacterium tuberculosis
- radiation therapy
- dna methylation
- early stage
- high grade
- particulate matter
- bone marrow
- hiv aids
- transcription factor
- cystic fibrosis
- lung function
- cell cycle arrest
- genome wide
- cell death
- hiv infected
- cell wall
- anaerobic digestion