Colorectal carcinoma occurring via the adenoma-carcinoma pathway in patients with serrated polyposis syndrome.
Fumika NakamuraYasushi SatoKoichi OkamotoYasuteru FujinoYasuhiro MitsuiKaizo KagemotoTomoyuki KawaguchiHiroshi MiyamotoNaoki MugurumaTomoko SonodaKoichi TsuneyamaTetsuji TakayamaPublished in: Journal of gastroenterology (2022)
Our results suggest that more than half of the CRCs, particularly those in the left-side colorectum, developed through the adenoma-carcinoma pathway in SPS patients. Adenoma was a risk factor for CRCs, suggesting its importance in colorectal carcinogenesis.