Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus.
Arnaud CarpentierJulie SheldonFlorian W R VondranRichard Jp BrownThomas PietschmannPublished in: Gut (2020)
This authentic human cell model is well suited to examine acute and chronic host-HCV interactions, particularly IFN-triggered antiviral effector functions and mechanisms of innate immune control of HCV infection.
Keyphrases
- hepatitis c virus
- drug induced
- liver failure
- liver injury
- innate immune
- human immunodeficiency virus
- stem cells
- respiratory failure
- endothelial cells
- dendritic cells
- aortic dissection
- cell therapy
- single cell
- immune response
- regulatory t cells
- induced pluripotent stem cells
- extracorporeal membrane oxygenation
- intensive care unit