Mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with age-related hearing loss.
Toru MiwaTatsuya KatsunoFan-Yan WeiKazuhito TomizawaPublished in: FEBS open bio (2023)
Previous studies have revealed that age-related hearing loss (AHL) in Cdk5 regulatory subunit associated protein 1 (Cdk5rap1)-knockout mice is associated with pathology in the cochlea. Here, we aimed to identify mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with AHL. Mitochondria in the spiral ganglion neurons (SGNs) and hair cells (HCs) were normal despite senescence; however, the mitochondria of types I, II, and IV spiral ligament fibrocytes were ballooned, damaged, and ballooned, respectively, in the stria vascularis. Our results suggest that the accumulation of dysfunctional mitochondria in the lateral wall, rather than the loss of HCs and SGNs, leads to the onset of AHL. Our results provide valuable information regarding the underlying mechanisms of AHL and the relationship between aberrant transfer RNA modification-induced hearing loss and mitochondrial dysfunction.
Keyphrases
- hearing loss
- cell cycle
- cell death
- oxidative stress
- induced apoptosis
- reactive oxygen species
- endoplasmic reticulum
- cell cycle arrest
- spinal cord
- cell proliferation
- dna damage
- high glucose
- endoplasmic reticulum stress
- health information
- minimally invasive
- neuropathic pain
- signaling pathway
- drug induced
- spinal cord injury
- social media