Gut mucosa alterations and loss of segmented filamentous bacteria in type 1 diabetes are associated with inflammation rather than hyperglycaemia.
Matthieu RoulandLucie BeaudoinOphélie RouxelLéo BertrandLucie CagninacciAzadeh SaffarianThierry PedronDalale GueddouriSandra GuilmeauAnne-Françoise BurnolLatif RachdiAsmaa TaziJuliette MourièsMaria RescignoNathalie VergnollePhilippe SansonettiUte Christine RognerAgnès LehuenPublished in: Gut (2021)
Our results demonstrate that gut mucosa alterations and dysbiosis in T1D are primarily linked to inflammation rather than hyperglycaemia. Anti-inflammatory treatment preserves gut homeostasis and protective commensal flora reducing T1D incidence.