Increase of cells expressing PD-1 and PD-L1 and enhancement of IFN-γ production via PD-1/PD-L1 blockade in bovine mycoplasmosis.

Shinya GotoSatoru KonnaiTomohiro OkagawaAsami NishimoriNaoya MaekawaSatoshi GondairaHidetoshi HiguchiMasateru KoiwaMotoshi TajimaJunko KoharaSatoshi OgasawaraYukinari KatoYasuhiko SuzukiShiro MurataKazuhiko Ohashi

Published in: Immunity, inflammation and disease (2017)

These results suggest that the PD-1/PD-L1 pathway could be involved in immune exhaustion of bovine mycoplasma-specific T cells. In conclusion, our study opens up a new perspective in the therapeutic strategy for bovine mycoplasmosis by targeting the immunoinhibitory receptor pathways.

Keyphrases

induced apoptosis
immune response
dendritic cells
signaling pathway
oxidative stress
cell proliferation
binding protein
pi k akt