CD3xCD19 DART molecule treatment induces non-apoptotic killing and is efficient against high-risk chemotherapy and venetoclax-resistant chronic lymphocytic leukemia cells.

Anne W J MartensSusanne R JanssenIngrid A M DerksHomer C Adams IiiLiat IzhakRoel van KampenSanne H ToninoEric ElderingGerritje J W van der WindtArnon P Kater

Published in: Journal for immunotherapy of cancer (2021)

These data show that CD3xCD19 DART in CLL leads to robust T cell activation and lysis of high-risk venetoclax resistant CLL cells through a non-apoptotic mechanism.

Keyphrases

chronic lymphocytic leukemia
induced apoptosis
cell death
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
big data
anti inflammatory
squamous cell carcinoma
radiation therapy
replacement therapy