Protective role of cGAS in NASH is related to the maintenance of intestinal homeostasis.

Marcelle RibeiroYeonhee ChoJeeval MehtaXiaojing WangMrigya BabutaChristopher CopelandHosni HusseinDonna CatalanoYanbo WangGyongyi Szabo

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

Our findings indicate that cGAS or STING deficiency exacerbate liver damage, steatosis, and inflammation in HF-HC-HSD diet-induced NASH, which might be linked to the disruption of the gut barrier.

Keyphrases

oxidative stress
insulin resistance
high fat diet
high fat diet induced
type diabetes
adipose tissue
skeletal muscle