Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production.

Eleonora CantoniIvan MerelliDavide StefanoniAlessandro Tomelleri Campochiaro CorradoVito GiordanoMaddalena PanigadaElena M BaldisseraLaura Merlo PichValentina NatoliAthanasios ZiogasJorge Domínguez-AndrésGiacomo De LucaDavide MazzaSamuel ZambranoDaniela GnaniMarina FerrariniElisabetta FerreroAlessandra AgrestiBarbara VerganiBiagio Eugenio LeoneSimone CenciAngelo RavelliMarco Matucci-CerinicAngelo D'AlessandroLeo A B JoostenLorenzo DagnaMihai G NeteaRaffaella MolteniGiulio Cavalli

Published in: Rheumatology (Oxford, England) (2023)

Myelomonocytic cells in GCA activate TI programs sustaining enhanced inflammatory activation with excess cytokine production.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
giant cell
public health
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation