Validation of a Flow Cytometry Live Cell-Based Assay to Detect Myelin Oligodendrocyte Glycoprotein Antibodies for Clinical Diagnostics.

Joseph A LopezSamuel D HoustonFiona TeaVera MerhebFiona X Z LeeSandy SmithDavid McDonaldAlicia ZouGanesha LiyanageDeepti PilliMartina DenkovaJeannette Lechner-ScottAnneke van der WaltMichael H BarnettStephen W ReddelSimon BroadleySudarshini RamanathanRussell C DaleDavid A BrownFabienne Brilot

Published in: The journal of applied laboratory medicine (2021)

Flow cytometry live CBAs show robust utility in determining MOG Ab serostatus. Streamlining and standardizing use of this assay for diagnostics would improve the accuracy and reliability of routine testing to aid diagnosis and treatment of patients with demyelination.

Keyphrases

flow cytometry
high throughput
clinical practice
white matter
multiple sclerosis
single cell