Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer.

Anna J WiecekStephen J CuttyDaniel KornaiMario Parreno-CentenoLucie E GourmetGuidantonio Malagoli TagliazucchiDaniel H JacobsonPing ZhangLingyun XiongGareth L BondAlexis R BarrMaria Secrier

Published in: Genome biology (2023)

We propose a G0 arrest transcriptional signature that is linked with therapeutic resistance and can be used to further study and clinically track this state.

Keyphrases

cell cycle arrest
cell death
pi k akt
papillary thyroid
gene expression
squamous cell
transcription factor
cell cycle
copy number
dna methylation
lymph node metastasis
cell proliferation
childhood cancer