The NGS technology for the identification of genes associated with the ALS. A systematic review.
Valentina PecoraroJessica MandrioliChiara CaroneAdriano ChioBryan J TraynorTommaso TrentiPublished in: European journal of clinical investigation (2020)
NGS seems to be a promising tool for the diagnosis of ALS in routine clinical practice. Its advantages are represented by an increased speed and a lowest sequencing cost, but patients' counselling could be problematic due to the discovery of frequent variants of unknown significance.