Specific inhibition of IL-6 receptor attenuates inflammatory bone loss in experimental periodontitis.

Gustavo H Apolinário VieiraAna Carolina Aparecida RivasKarine Figueiredo CostaLuis Fernando Ferreira OliveiraKleber Tanaka SuzukiMichel Reis MessoraMilla Sprone RicoldiAdriana Luisa Gonçalves de AlmeidaMario Taba Júnior

Published in: Journal of periodontology (2021)

The inhibition of IL-6-mediated proinflammatory activity by IL-6R blocking reduced alveolar bone resorption and attachment loss supported by the modulation of the Th17 periodontal response. Considering the inflammatory status, modulatory therapy may be a promising approach to periodontal disease.

Keyphrases

bone loss
oxidative stress
bone mineral density
postmenopausal women