A Non-Peptidic S100A9 Specific Ligand for Optical Imaging of Phagocyte Activity In Vivo.

Tom VöllerAndreas FaustJohannes RothMichael SchäfersThomas VoglSven Hermann

Published in: Molecular imaging and biology (2019)

Cy5.5-CES271 shows significant accumulation in models of inflammatory diseases and specific binding to S100A9 in vivo. This study, for the first time, demonstrates the potential of a small molecule non-peptidic tracer enabling imaging of S100A9 as a marker of local phagocyte activity in inflammatory scenarios suggesting this compound class for translational attempts.

Keyphrases

high resolution
small molecule
oxidative stress
climate change
computed tomography
high speed
positron emission tomography
fluorescence imaging
risk assessment
pet imaging