Stimuli-responsive biotin-anchored prodrug for the targeted delivery of anti-cancer agent NBDHEX with turn-on NIR fluorescence.

Rahul Kesarwani Nikita Pal Krishna Pada Bhabak

Published in: Chemical communications (Cambridge, England) (2024)

Biothiol-activatable prodrug RK-296 was designed for the delivery of potent anti-cancer agent NBDHEX with concomitant turn-on near infrared (NIR) fluorescence. NBDHEX exhibits anti-cancer activity by selectively inhibiting glutathione- S -transferase pi (GSTP1), which is overexpressed in cancer cells and responsible for the inactivation of chemotherapeutic drugs. The sustained release of NBDHEX from the prodrug would be useful for ameliorating the off-target side-effects of NBDHEX.

Keyphrases

fluorescent probe
drug release
cancer therapy
living cells
fluorescence imaging
drug delivery
single molecule
photodynamic therapy
sensitive detection
energy transfer
anti inflammatory