Transient Systemic Autophagy Inhibition Is Selectively and Irreversibly Deleterious to Lung Cancer.

Khoosheh Khayati Vrushank Bhatt Taijin Lan Fawzi Alogaili Wenping Wang Enrique Lopez Zhixian Sherrie Hu Samantha Gokhale Liam D Cassidy Masashi Narita Ping Xie Eileen P White Jessie Yanxiang Guo

Published in: Cancer research (2022)

Transient loss of systemic autophagy causes irreversible damage to tumors by suppressing cancer cell metabolism and promoting antitumor immunity, supporting autophagy inhibition as a rational strategy for treating lung cancer. See related commentary by Gan, p. 4322.

Keyphrases

cell death
oxidative stress
endoplasmic reticulum stress
signaling pathway
cerebral ischemia
drug induced
blood brain barrier