Subcortical amyloid relates to cortical morphology in cognitively normal individuals.
Shady RahayelChristian BoctiPénélope Sévigny DupontMaude JoannetteMarie Maxime LavalléeJim NikelskiHoward ChertkowSven JoubertPublished in: European journal of nuclear medicine and molecular imaging (2019)
In cognitively normal individuals, subcortical Aβ is associated with cortical volume, and this effect was driven by surface area with or without thickness. Aβ-associated cortical changes were found in the default mode network and affected cognitive performance. Our findings demonstrate the importance of studying subcortical Aβ and cortical surface area in normal ageing.