Elevated cardiac biomarkers and outcomes in children and adolescents with acute COVID-19.
Michael A FremedEmma W HealyNak Hyun ChoiEva W CheungTarif A ChoudhuryPengfei JiangLeonardo LibermanJason ZuckerIrene D LytriviThomas J StarcPublished in: Cardiology in the young (2022)
Cardiac involvement associated with multi-system inflammatory syndrome in children has been extensively reported, but the prevalence of cardiac involvement in children with SARS-CoV-2 infection in the absence of inflammatory syndrome has not been well described. In this retrospective, single centre, cohort study, we describe the cardiac involvement found in this population and report on outcomes of patients with and without elevated cardiac biomarkers. Those with multi-system inflammatory syndrome in children, cardiomyopathy, or complex CHD were excluded. Inclusion criteriaz were met by 80 patients during the initial peak of the pandemic at our institution. High-sensitivity troponin T and/or N-terminal pro-brain type natriuretic peptide were measured in 27/80 (34%) patients and abnormalities were present in 5/27 (19%), all of whom had underlying comorbidities. Advanced respiratory support was required in all patients with elevated cardiac biomarkers. Electrocardiographic abnormalities were identified in 14/38 (37%) studies. Echocardiograms were performed on 7/80 patients, and none demonstrated left ventricular dysfunction. Larger studies to determine the true extent of cardiac involvement in children with COVID-19 would be useful to guide recommendations for standard workup and management.
Keyphrases
- left ventricular
- end stage renal disease
- coronavirus disease
- sars cov
- newly diagnosed
- ejection fraction
- chronic kidney disease
- young adults
- oxidative stress
- heart failure
- prognostic factors
- acute myocardial infarction
- hypertrophic cardiomyopathy
- left atrial
- mitral valve
- case report
- multidrug resistant
- risk factors
- adipose tissue
- metabolic syndrome
- patient reported outcomes
- respiratory syndrome coronavirus
- weight loss
- acute respiratory distress syndrome
- skeletal muscle
- extracorporeal membrane oxygenation
- coronary artery disease
- tyrosine kinase
- insulin resistance
- brain injury
- subarachnoid hemorrhage
- respiratory failure
- patient reported