Activation of Epidermal Growth Factor Receptor Sensitizes Glioblastoma Cells to Hypoxia-Induced Cell Death.
Anna-Luisa LugerNadja I LorenzHans UrbanIris DivéAnna L EngelFlorian StrassheimerKatja DettmerPia S ZeinerShabnam ShaidNina StruveMalte KriegsUte HofmannPeter J OefnerPatrick N HarterJoachim P SteinbachMichael W RonellenfitschPublished in: Cancers (2020)
The finding that EGFR activation renders GB cells susceptible to starvation could help to identify a subgroup of patients more likely to benefit from starvation-inducing therapies.
Keyphrases
- epidermal growth factor receptor
- induced apoptosis
- cell cycle arrest
- cell death
- tyrosine kinase
- advanced non small cell lung cancer
- endoplasmic reticulum stress
- small cell lung cancer
- newly diagnosed
- signaling pathway
- oxidative stress
- clinical trial
- prognostic factors
- cell proliferation
- patient reported
- open label