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Rh(III)-catalyzed [4 + 1] cyclization of aryl substituted pyrazoles with cyclopropanols via C-H activation.

Wenxi ChenYan MaoMin WangFei LingChangchang LiZhang-Pei ChenJinzhong Yao
Published in: Organic & biomolecular chemistry (2023)
A rhodium-catalyzed formal [4 + 1]-cyclization reaction of aryl substituted pyrazoles with cyclopropanols via C-H bond activation/cyclization processes to selectively construct a series of carbonyl functionalized pyrazolo[5,1- a ]isoindoles is described. The reaction features good functional group compatibility and a broad substrate scope with respect to both cyclization components with up to 84% yields. Mechanistic studies indicated that the C-H cleavage might be the rate-determining step in this transformation.
Keyphrases
  • molecular docking
  • room temperature
  • quantum dots
  • electron transfer
  • mass spectrometry
  • simultaneous determination
  • visible light