Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS-275.
Bettina ZierfussIsabelle WeinhoferAgnieszka BudaNiko PopitschLena HessVerena MoosSimon HametnerStephan KempWolfgang KöhlerSonja Forss-PetterChristian SeiserJohannes BergerPublished in: Annals of clinical and translational neurology (2020)
These findings identify class I-HDAC inhibition as a potential novel strategy to prevent disease promoting foam cell formation in CNS inflammation.