Usefulness of an RNA extraction-free test for the multiplexed detection of ALK , ROS1 , and RET gene fusions in in real life FFPE specimens of non-small cell lung cancers.
Francesca DamiolaAlberti LaurentMansuet-Lupo AudreyDamotte DianeHofman VéroniqueTixier LuciePenault-Llorca FréderiqueRouquette IsabelleVignaud Jean MichelCazes AurelieForest FabienBegueret HuguesGibault LaureBadoual CécileCayre AnneTaranchon-Clermont EstelleDuc AdelineMc Leer AnneLantuejoul SylviePublished in: Expert review of molecular diagnostics (2023)
Overall, the HTG EdgeSeq assay offers comparable sensitivities and specificity than other RNA sequencing techniques, with the advantage that it can be used on very small and old samples collected multicentrically.