Anti-Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis.

Zhuo ChenHao Xu

Published in: Evidence-based complementary and alternative medicine : eCAM (2014)

Tanshinone IIA (Tan II A) is widely used in the treatment of cardiovascular diseases as an active component of Salvia miltiorrhiza Bunge. It has been demonstrated to have pleiotropic effects for atherosclerosis. From the anti-inflammatory and immunomodulatory mechanism perspective, this paper reviewed major progresses of Tan IIA in antiatherosclerosis research, including immune cells, antigens, cytokines, and cell signaling pathways.

Keyphrases

anti inflammatory
cardiovascular disease
signaling pathway
single cell
pi k akt
coronary artery disease
mesenchymal stem cells
cardiovascular events
induced apoptosis
oxidative stress
bone marrow
combination therapy
endoplasmic reticulum stress