Immune and metabolic perturbations in COVID-19-associated pulmonary mucormycosis: A transcriptome analysis of innate immune cells.

Manpreet Dhaliwal Valliappan MuthuArunima SharmaKhem Raj Shivaprakash Mandya RudramurthyRitesh AgarwalHarsimran KaurAmit RawatSurjit SinghArunaloke Chakrabarti

Published in: Mycoses (2024)

We identified significant alterations in the metabolic pathways possibly leading to cellular iron overload and a hyperglycaemic state. Immune responses revealed altered recognition, signalling, effector functions and a pro-inflammatory state in monocytes and neutrophils from CAPM patients.

Keyphrases

immune response
end stage renal disease
dendritic cells
coronavirus disease
sars cov
single cell
newly diagnosed
chronic kidney disease
pulmonary hypertension
gene expression
peritoneal dialysis
prognostic factors
rna seq
genome wide
regulatory t cells
respiratory syndrome coronavirus
type iii