Detection of ROS1-positive non-small cell lung cancer on cytological specimens using immunocytochemistry.

Tatjana VlajnicSpasenija SavicAudrey BarascudBetty BaschieraMichel BihlBruno GrilliMichelle HerzogJulien RebetezLukas Bubendorf

Published in: Cancer cytopathology (2018)

ROS1 ICC is an accurate method for the detection of ROS1 rearrangements in NSCLC. Given the high costs and technical challenges of FISH and the rarity of ROS1 rearrangements, ICC is rapid and therefore well suited as a screening method. Cases with equivocal or positive findings on ICC can be confirmed by FISH or molecular tests. Cancer Cytopathol 2018;126:421-9. © 2018 American Cancer Society.

Keyphrases

cell death
dna damage
reactive oxygen species
papillary thyroid
loop mediated isothermal amplification
squamous cell
small cell lung cancer
label free
real time pcr
lymph node metastasis
oxidative stress
high resolution
mass spectrometry
fine needle aspiration