Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA.

Judith DerdelinckxMaría José MansillaMaxime De LaereWai-Ping LeeJuan Navarro-BarriusoInez WensIrene NkansahJasmijn DaansHans De ReuAneta Jolanta KelirisJohan Van AudekerkeVerdi VanreuselZoë PietersAnnemie Van der LindenMarleen VerhoyeGeert MolenberghsNiel HensHerman GoossensBarbara WillekensPatrick CrasPeter PonsaertsZwi N BernemanEva María Martínez-CáceresNathalie Cools

Published in: Journal of neuroinflammation (2019)

Electroporation with mRNA is an efficient and versatile tool to generate myelin-presenting tolDC that are capable to stabilize the clinical score in EAE. These results pave the way for further research into mRNA-electroporated tolDC treatment as a patient-tailored therapy for MS.

Keyphrases

dendritic cells
regulatory t cells
case report
immune response
mass spectrometry
binding protein
drug delivery
multiple sclerosis
ms ms
white matter
smoking cessation
replacement therapy