Clinical and microbiological characterization of sepsis and evaluation of sepsis scores.
Andre FuchsTafese Beyene TufaJohannes HörnerZewdu HurissaTamara NordmannMatthias BosselmannSileshi AbdissaAbebe SorsaHans Martin OrthBjörn-Erik Ole JensenColin MacKenzieKlaus PfefferAchim J KaaschJohannes G BodeDieter HäussingerTorsten FeldtPublished in: PloS one (2021)
Sepsis is commonly unrecognized and associated with high mortality, showing the need for reliable and easy-applicable tools to support early recognition. The established sepsis scores were either of limited applicability (SOFA) or, as in the case of qSOFA, were significantly impaired in their sensitivity and specificity, demonstrating the need for further evaluation and adaptation to local settings. Regional factors like malaria endemicity and HIV prevalence might influence the performance of different scores. Ineffective empirical treatment due to antimicrobial resistance is common and associated with mortality. Local antimicrobial resistance statistics are needed for guidance of calculated antimicrobial therapy to support reduction of sepsis mortality.
Keyphrases
- antimicrobial resistance
- septic shock
- acute kidney injury
- intensive care unit
- risk factors
- cardiovascular events
- hepatitis c virus
- antiretroviral therapy
- stem cells
- hiv positive
- human immunodeficiency virus
- type diabetes
- hiv testing
- hiv aids
- mesenchymal stem cells
- men who have sex with men
- replacement therapy
- cell therapy