Sacubitril/valsartan decreases mortality in the rat model of the isoprenaline-induced takotsubo-like syndrome.

Anwar AliBjörn RedforsJessica AlkhouryJonatan OrasMarcus HenricssonJan BorenElias BjörnsonAaron EspinosaMalin LevinLi-Ming GanElmir Omerovic

Published in: ESC heart failure (2021)

Pretreatment with sacubitril/valsartan but not with valsartan reduces mortality and attenuates isoprenaline-induced apical akinesia in the TTS-like model in rats. Sacubitril/valsartan could be a potential treatment option in patients with TTS in humans.

Keyphrases

ejection fraction
high glucose
diabetic rats

cardiovascular events
drug induced
risk factors

endothelial cells
oxidative stress
cardiovascular disease

type diabetes
coronary artery disease
case report